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Add-OnClinical Trials & Rare Diseases
Clinical Trials & Rare Diseases
This package has 3 modules. The Drug-Protein Relationships and Drug Targets Module has 4 tables. Preview the first five rows of each table or Explore the schema
Drug-Protein Relationships and Drug Targets Module
4 Tables
Describes the relationship between drugs and targets, enzymes, carriers, or transporters. Annotation includes the pharmacological action, and the type of interaction (antagonist, agonist, substrate, inhibitor, or inducer).
biodb_id | name | kind | organism | plus_export |
|---|---|---|---|---|
BE0000001 | Peptidoglycan synthase FtsI | protein | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | 0 |
BE0000002 | Histidine decarboxylase | protein | Humans | 0 |
BE0000003 | Glutaminase liver isoform, mitochondrial | protein | Humans | 0 |
BE0000004 | Coagulation factor XIII A chain | protein | Humans | 0 |
BE0000005 | Nitric oxide synthase, inducible | protein | Humans | 0 |
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biodb_id | component_type | component_id |
|---|---|---|
BE0000001 | Polypeptide | P45059 |
BE0000002 | Polypeptide | P19113 |
BE0000003 | Polypeptide | Q9UI32 |
BE0000004 | Polypeptide | P00488 |
BE0000005 | Polypeptide | P35228 |
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id | type | drug_id | biodb_id | pdb_id | position | pharmacological_action | antagonist | agonist | substrate | inhibitor | inducer | other_action | inducer_strength | inhibitor_strength | induction_clinically_sig | inhibition_clinically_sig |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | TargetBond | 1 | BE0000048 | 1 | yes | 0 | 0 | 0 | 1 | 0 | unknown | 0 | 0 | |||
2 | TargetBond | 2 | BE0000767 | 1 | yes | 0 | 0 | 0 | 0 | 0 | binder | 0 | 0 | |||
3 | TargetBond | 4 | BE0000658 | 1 | yes | 0 | 0 | 0 | 0 | 0 | ligand | 0 | 0 | |||
4 | TargetBond | 5 | BE0000704 | 1 | yes | 0 | 0 | 0 | 1 | 0 | antibody | unknown | 0 | 0 | ||
5 | TargetBond | 6 | BE0000048 | 1 | yes | 0 | 0 | 0 | 1 | 0 | unknown | 0 | 0 |
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uniprot_id | name | uniprot_name | gene_name | organism_id | molecular_weight | theoretical_pi | general_function | specific_function | signal_regions | transmembrane_regions | pdb_ids | genbank_gene_id | genbank_protein_id | genecard_id | locus | genatlas_id | hgnc_id | meta_cyc_id | ncbi_sequence_ids | tissue_specificity | cofactor | subunit | cellular_location | amino_acid_sequence | gene_sequence |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A0A023W3H0 | Class D OXA-48 carbapenemase | A0A023W3H0_KLEPN | OXA-48 | 144 | 16920.07 | penicillin binding | >lcl|BSEQ0022471|Class D OXA-48 carbapenemase
VVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDY
GNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYI
IRAKTGYSTRIEPKIGWWVGWVELD | ||||||||||||||||||
A0A024R1R8 | Translation machinery-associated protein 7B | TMA7B_HUMAN | TMA7B | 154 | 7091.405 | TMA7B | HGNC:53893 | >lcl|BSEQ0069905|Translation machinery-associated protein 7B
MSSHEGGKKKALKQPKKQAKEMDEEEKAFKQKQKEEQKKLEVLKAKVVGKGPLATGGIKK
SGKK | |||||||||||||||||
A0A024R8I1 | Voltage-dependent N-type calcium channel subunit alpha | A0A024R8I1_HUMAN | CACNA1B | 154 | 111676.12 | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. | Voltage-gated calcium channel activity | 99-116
136-156
223-245
333-355
484-504
510-527
548-566
609-631
687-709 | Membrane | >lcl|BSEQ0052085|Voltage-dependent N-type calcium channel subunit alpha
MVRFGDELGGRYGGPGGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYN
PIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPD
GDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWKVMDFVVVLTGILA
TAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAII
GLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNI
LFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA
KERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAA
TKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVK
AQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRS
YFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVV
SLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQIL
TGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK
DEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNL
RASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVGGKARPEAAE
APEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKEAAGPP
EARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKESPRQGRAARAAPRR
PPSGAPGGGERGGAGAAAPGPAQGAACSRGCGEGDHGEGGHGEGG | |||||||||||||||
A0A024RBG1 | Diphosphoinositol polyphosphate phosphohydrolase NUDT4B | NUD4B_HUMAN | NUDT4B | 154 | 20434.03 | Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | bis(5'-adenosyl)-hexaphosphatase activity | NUDT4B | 12q22 | HGNC:18012 | Cytoplasm | >lcl|BSEQ0064393|Diphosphoinositol polyphosphate phosphohydrolase NUDT4B
MMKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGMEPEEEPG
GAAVREVYEEAGVKGKLGRLLGIFEQNQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREW
FKVEDAIKVLQCHKPVHAEYLEKLKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSV
R | |||||||||||||
A0A024WHL8 | Multidrug resistance protein 2 | A0A024WHL8_PLAFA | 2228 | 119382.33 | ABC-type heme transporter activity | 27-49
69-88
108-126
138-161
360-381
401-418
479-499
505-522
596-614
626-647 | Membrane | >lcl|BSEQ0054224|Multidrug resistance protein 2
MDVSNYEYLRSYGIKNELKRKRTHKKIIIYHLLDIIIFFLLFFSCYNFNLELCYKYEKAI
FYNFFKSSVDLFLLNVIRIIYTVILFRLHKKLTELNTLGKVYVLSRHITGILVILNVIKM
INYSYVIKSENPLYNTNMYLITLKVLFMVYSMISSIYYYFIQFKLYNIKKKYIIARVELE
KILINDIKSKKYNIYKSDENSGLLGTDNNSTIMNNEYLNLDYKNLLDMNISYNKLNEKIN
NDIINNTSDVQEKNMDYNDIHNFQKKKKSSNFAYLNFFHKESKDNKIDVKESFLNKRYGS
NKRSSKIYDNNNNNNNNNNNNINSKIDYLENNITYTEFKKILLPYLWPSKRIDMKGNSSI
LRTYIVLIFLFILVSKVFSVISPIYLGWASNEVLKKSLSSSVYYLGLYVTFFFISKFLKE
VCGVLYSQVQQSAFIELQESIFQTFHNLSYEWYSSKNSGGIMRIVDRGTESANNLMSSVL
MYIIPATIEGLITCVIFIFKYKNSLLGSVLFIGLTLYIYSTIKITKWRKKIRTKANEMDN
VYHDIAHDSLTNYENVKYFSNEKFEIKKFCNALSNYHRYNLKILNSLGILNTVQQFILNG
TLFFTLLCVIYMIVKEGSDPGTFISVVVYTSNVFAPLSILGTLYATIIKSFTDISDLIDI
LRDKIDISNDKNLKNFDLTSQEKKFGVSIEFNNVHFNYPTQPLHTSLKDINIYIKPGTTC
ALVGHTGSGKTTISKLLYRFYDSKGEIKIGGRNINEYTRNSIRNIIGIVPQDTILFNESI
KYNILYGKLDATEEELIQAVKSAQLYDFIQSLPKKWDTLVGDKGVKLSGGERQRISIARC
LLKDPKIVIFDEATSSLDSRTEYLFQKAVEDLRKNRTIIIIAHKLCTITTAELIILLNKG
KIIERGTHLDLLKCNGEYTEMWNMQSKSNEPHTETNSSIDKDDVNKNNNKNNDVILNTCK
NDITTSFRSNSEKSSQEFSDASNHIKQSKTSNDHNNNINVHKKNEQEQLFLTNDKTDMDD
NMNNKKK |
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Showing 4 of 4 tables
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