Disease Prioritization Data Package
This package has 16 modules. The Drug-Protein Relationships and Drug Targets Module has 4 tables. Preview the first five rows of each table or Explore the schema
Drug-Protein Relationships and Drug Targets Module
4 Tables
Describes the relationship between drugs and targets, enzymes, carriers, or transporters. Annotation includes the pharmacological action, and the type of interaction (antagonist, agonist, substrate, inhibitor, or inducer).
biodb_id | name | kind | organism | plus_export |
|---|---|---|---|---|
BE0000001 | Peptidoglycan D,D-transpeptidase FtsI | protein | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) | 0 |
BE0000002 | Histidine decarboxylase | protein | Humans | 0 |
BE0000003 | Glutaminase liver isoform, mitochondrial | protein | Humans | 0 |
BE0000004 | Coagulation factor XIII A chain | protein | Humans | 0 |
BE0000005 | Nitric oxide synthase, inducible | protein | Humans | 0 |
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biodb_id | component_type | component_id |
|---|---|---|
BE0000001 | Polypeptide | P45059 |
BE0000002 | Polypeptide | P19113 |
BE0000003 | Polypeptide | Q9UI32 |
BE0000004 | Polypeptide | P00488 |
BE0000005 | Polypeptide | P35228 |
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id | type | drug_id | biodb_id | pdb_id | position | pharmacological_action | antagonist | agonist | substrate | inhibitor | inducer | other_action | inducer_strength | inhibitor_strength | induction_clinically_sig | inhibition_clinically_sig |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | TargetBond | 1 | BE0000048 | 1 | yes | 0 | 0 | 0 | 1 | 0 | unknown | 0 | 0 | |||
2 | TargetBond | 2 | BE0000767 | 1 | yes | 0 | 0 | 0 | 0 | 0 | binder | 0 | 0 | |||
3 | TargetBond | 4 | BE0000658 | 1 | yes | 0 | 0 | 0 | 0 | 0 | ligand | 0 | 0 | |||
4 | TargetBond | 5 | BE0000704 | 1 | yes | 0 | 0 | 0 | 1 | 0 | antibody | unknown | 0 | 0 | ||
5 | TargetBond | 6 | BE0000048 | 1 | yes | 0 | 0 | 0 | 1 | 0 | unknown | 0 | 0 |
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uniprot_id | name | uniprot_name | gene_name | organism_id | molecular_weight | theoretical_pi | general_function | specific_function | signal_regions | transmembrane_regions | pdb_ids | genbank_gene_id | genbank_protein_id | genecard_id | locus | genatlas_id | hgnc_id | meta_cyc_id | ncbi_sequence_ids | tissue_specificity | cofactor | subunit | cellular_location | amino_acid_sequence | gene_sequence |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A0A023W3H0 | OXA-48 carbapenemase | A0A023W3H0_KLEPN | OXA-48 | 144 | 16920.07 | penicillin binding | >lcl|BSEQ0022471|Class D OXA-48 carbapenemase
VVKDEHQVFKWDGQTRDIATWNRDHNLITAMKYSVVPVYQEFARQIGEARMSKMLHAFDY
GNEDISGNVDSFWLDGGIRISATEQISFLRKLYHNKLHVSERSQRIVKQAMLTEANGDYI
IRAKTGYSTRIEPKIGWWVGWVELD | ||||||||||||||||||
A0A024R1R8 | Translation machinery-associated protein 7B | TMA7B_HUMAN | TMA7B | 154 | 7091.405 | TMA7B | HGNC:53893 | >lcl|BSEQ0069905|Translation machinery-associated protein 7B
MSSHEGGKKKALKQPKKQAKEMDEEEKAFKQKQKEEQKKLEVLKAKVVGKGPLATGGIKK
SGKK | |||||||||||||||||
A0A024RBG1 | Diphosphoinositol polyphosphate phosphohydrolase NUDT4B | NUD4B_HUMAN | NUDT4B | 154 | 20434.03 | Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA | bis(5'-adenosyl)-hexaphosphatase activity | NUDT4B | 12q22 | HGNC:18012 | Cytoplasm | >lcl|BSEQ0064393|Diphosphoinositol polyphosphate phosphohydrolase NUDT4B
MMKFKPNQTRTYDREGFKKRAACLCFRSEQEDEVLLVSSSRYPDQWIVPGGGMEPEEEPG
GAAVREVYEEAGVKGKLGRLLGIFEQNQDRKHRTYVYVLTVTEILEDWEDSVNIGRKREW
FKVEDAIKVLQCHKPVHAEYLEKLKLGCSPANGNSTVPSLPDNNALFVTAAQTSGLPSSV
R | |||||||||||||
A0A024WHL8 | Multidrug resistance protein 2 | A0A024WHL8_PLAFA | 2228 | 119382.33 | ABC-type heme transporter activity | 27-49
69-88
108-126
138-161
360-381
401-418
479-499
505-522
596-614
626-647 | Membrane | >lcl|BSEQ0054224|Multidrug resistance protein 2
MDVSNYEYLRSYGIKNELKRKRTHKKIIIYHLLDIIIFFLLFFSCYNFNLELCYKYEKAI
FYNFFKSSVDLFLLNVIRIIYTVILFRLHKKLTELNTLGKVYVLSRHITGILVILNVIKM
INYSYVIKSENPLYNTNMYLITLKVLFMVYSMISSIYYYFIQFKLYNIKKKYIIARVELE
KILINDIKSKKYNIYKSDENSGLLGTDNNSTIMNNEYLNLDYKNLLDMNISYNKLNEKIN
NDIINNTSDVQEKNMDYNDIHNFQKKKKSSNFAYLNFFHKESKDNKIDVKESFLNKRYGS
NKRSSKIYDNNNNNNNNNNNNINSKIDYLENNITYTEFKKILLPYLWPSKRIDMKGNSSI
LRTYIVLIFLFILVSKVFSVISPIYLGWASNEVLKKSLSSSVYYLGLYVTFFFISKFLKE
VCGVLYSQVQQSAFIELQESIFQTFHNLSYEWYSSKNSGGIMRIVDRGTESANNLMSSVL
MYIIPATIEGLITCVIFIFKYKNSLLGSVLFIGLTLYIYSTIKITKWRKKIRTKANEMDN
VYHDIAHDSLTNYENVKYFSNEKFEIKKFCNALSNYHRYNLKILNSLGILNTVQQFILNG
TLFFTLLCVIYMIVKEGSDPGTFISVVVYTSNVFAPLSILGTLYATIIKSFTDISDLIDI
LRDKIDISNDKNLKNFDLTSQEKKFGVSIEFNNVHFNYPTQPLHTSLKDINIYIKPGTTC
ALVGHTGSGKTTISKLLYRFYDSKGEIKIGGRNINEYTRNSIRNIIGIVPQDTILFNESI
KYNILYGKLDATEEELIQAVKSAQLYDFIQSLPKKWDTLVGDKGVKLSGGERQRISIARC
LLKDPKIVIFDEATSSLDSRTEYLFQKAVEDLRKNRTIIIIAHKLCTITTAELIILLNKG
KIIERGTHLDLLKCNGEYTEMWNMQSKSNEPHTETNSSIDKDDVNKNNNKNNDVILNTCK
NDITTSFRSNSEKSSQEFSDASNHIKQSKTSNDHNNNINVHKKNEQEQLFLTNDKTDMDD
NMNNKKK | |||||||||||||||||
A0A045ISQ8 | Cytochrome D Ubiquinol oxidase subunit II | A0A045ISQ8_MYCTX | cydB | 13 | 37626.835 | electron transfer activity | 6-24
87-107
119-142
162-188
200-221
227-247
254-275
303-326 | >lcl|BSEQ0052081|Cytochrome D Ubiquinol oxidase subunit II
MVLQELWFGVIAALFLGFFILEGFDFGVGMLMAPFAHVGMGDPETHRRTALNTIGPVWDG
NEVWLITAGAAIFAAFPGWYATVFSALYLPLLAILFGMILRAVAIEWRGKIDDPKWRTGA
DFGIAAGSWLPALLWGVAFAILVRGLPVDANGHVALSIPDVLNAYTLLGGLATAGLFSLY
GAVFIALKTSGPIRDDAYRFAVWLSLPVAGLVAGFGLWTQLAYGKDWTWLVLAVAGCAQA
AATVLVWRRVSDGWAFMCTLIVVAAVVVLLFGALYPNLVPSTLNPQWSLTIHNASSTPYT
LKIMTWVTAFFAPLTVAYQTWTYWVFRQRISAERIPPPTGLARRAP |
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Showing 4 of 4 tables