Biomedical Knowledge Data Package
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Pharmacogenomics Module
1 Tables
A list of single nucleotide polymorphisms (SNPs) relevant to drug activity or metabolism, and the effects these may have on pharmacological activity. SNP effects in the patient may require close monitoring, a dosage adjustment, or a change in therapy.
id | drug_id | kind | uniprot_id | protein_name | gene_name | rs_id | allele_name | defining_change | description | pubmed_ids |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 2 | 1 | P12318 | Low affinity immunoglobulin gamma Fc region receptor II-a | FCGR2A | rs1801274 | H allelle | Patients with this genotype may have increased progression-free survival time when using cetuximab to treat colorectal cancer. | 17704420 | |
2 | 2 | 1 | P08637 | Low affinity immunoglobulin gamma Fc region receptor III-A | FCGR3A | rs396991 | G > T | Patients with this genotype have increased progression-free survival time when using cetuximab to treat colorectal cancer. | 17704420 | |
4 | 65 | 1 | P08637 | Low affinity immunoglobulin gamma Fc region receptor III-A | FCGR3A | rs1801274 | CC Allele (homozygous) | Patients with this genotype have increased ACR20 response when using infliximab to treat rheumatoid arthritis. | 18930989 | |
5 | 72 | 0 | P04626 | Receptor tyrosine-protein kinase erbB-2 | ERBB2 | rs1136201 | G Allele, heterozygote | Patients with this genotype have increased risk of cardiotoxicity with trastuzumab. | 17693647 | |
6 | 73 | 1 | P08637 | Low affinity immunoglobulin gamma Fc region receptor III-A | FCGR3A | rs396991 | FCGR3A | T > G | Patients with this genotype have increased frequency of anti-tumor response when using rituximab to treat diffuse large B-cell lymphoma, follicular lymphoma, or [follicular non-Hodgkin lymphoma]. | 16609067 |
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